Yes, I would think there must be some difference, if not, I would think a Pleo with a low activeness level and high physical level would have serious issues. I'm thinking it might be resistance to sickness or something along those lines, but haven't tried testing this out at all. She does seem very sensitive to the dark compared to some of my other RBs, but this probably has to do with her low courage level. Taking Pleos to school sounds great! The college I'm at used to do research with Ugobes, but apparently there are some restrictions on what programming alterations can be done to RBs, so they can't continue the research with the newer model.
I currently have five working RBs (Chris, Celeste, Madi, Sybil and Buddy) and two bricked ones (Mimi and Morty), but I currently have Buddy on hold for a member here on the forums who wants to give him a new home since he hasn't been really fitting in here (I bought him mainly for use in a volunteer program I did and haven't been super connected with him since the program ended). I still only have my two Ugobes (Sumio and Phoenix), but also have a bricked prototype Pleo named Peep.
Hopefully you can find a name for your newest RB, her design has always been a favorite of mine! The pink/mauve eye patches and teal eyes go really well together! I have some new pictures of Sybil on my phone, just need to find the time to load them onto the computer. She visited college with me last week and one of the girls in the suite across from me got to meet her and was completely smitten with her!